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Os primeiros sinais do melanoma, o câncer de pele mais letal e agressivo, são alterações no tamanho, na cor ou aparência de uma pinta. A pele clara caucasiana e a exposição solar excessiva são seus fatores de risco mais conhecidos. No entanto, existe uma variante do melanoma que foge dessa regra e aparece em áreas não expostas ao sol, como a palma da mão, a planta do pé e as unhas, e pode se manifestar em pessoas de qualquer etnia, incluindo os afrodescendentes e asiáticos.
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