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A sensação de boca seca e gosto amargo ao acordar pode estar relacionada a alterações no sistema digestivo, especialmente ao refluxo, incluindo o refluxo biliar. Durante a noite, quando estamos deitados, o conteúdo do estômago e até do duodeno pode retornar em direção ao esôfago e à cavidade oral. No caso do refluxo biliar, há presença de bile — uma substância produzida pelo fígado e armazenada na vesícula biliar — que tem sabor caracteristicamente amargo. Esse retorno pode deixar esse gosto na
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